Creative tinkerers and developers, along with recent advances in optogenetics, genetically-encoded Calcium indicators and miniaturized optics and electronics made head-mountable microscopes a popular tool. Innovations from the founders of Inscopix and the UCLA team with their Miniscope have made this technology more accessible.
The NINscope (developed and published by de Groot et al., 2019 from the Netherlands Institute for Neuroscience) is a more recent development. It is a smaller footprint, light weight hybrid of the Miniscope, with several other interesting integrated features. It is ideal for use on small freely behaving animals, or when two simultaneous recording areas is of interest, since it is small enough for a mouse to have two NINscope's mounted at the same time.
As part of NeuroGig's Open-Hardware Support we now offer the NINscope available to order online in our store as a complete product (tested and under warranty). You also have the option to buy a NeuroGig NINscope Kit should you like to try the assembly and installation yourself.
NeuroGig offers you various options to fit your budget and preferences. You can opt to purchase the NeuroGig NINscope Kit only, where you handle the assembly. Or, you buy the Kit and let us handle the assembly and testing with optional installation. And yes, we do provide a warranty on our workmanship!
Alternatively, we provide the fully assembled product with warranty and optional installation and product training (non-surgery related).
For more information on miniscope designs and features, please read further in the publication by de Groot et al., 2019. They described their instrument design, manufacturing methods and functionality in detail here.
Weight - 1.6g
Yes, this includes the housing, optics & PCBs!
Footprint -6.5 x 7.5 mm baseplate
Sensor -CMOS 752x480 pixels (Python480)
with Kyocera CMOS clock oscillator
Pixel Size - 4.8 µm
Inertial Measurement Unit -
Yes, 3D accelerometer (STMicoreectronics LSM6DSLTR)
LED Driver -
Yes, 2 LED drivers and 12C I/O expander
Accuracy -1 ms
Optogenetic stimulation LED probe -
Yes, custom probe
Multi-region recordings -
Inter-baseplate distance -
Coaxial Cable -
CMOS connects via FPD-Link III and coaxial to USB controller on the DAQ board
Excitation/Emission Filters size -
3.5x3.5x0.5 mm Excitation/ 4x4x1 mm Emission
Dichroic Mirror -
Chroma T495lpxr (3.5x5x0.5 mm)
GRIN lens -
Yes, #64-519 Edmund Optics Grin lens with 1.8 mm diameter *implanted or glued into baseplate
Numerical Aperture -
UCLA Miniscope DAQ card with minor modifications
Time per recording session -
2-11 min with brief intermissions
*EnvisionTec Micro Plus Advantage & Formlabs Form 2
Open Source Software -
Yes, platform independent user interface with two channels for recordings and an additional USB webcam for behaviour video footage, together with time stamps and integrated control
For more information on the Open-Hardware Support we offer, please watch our short introduction video.
Please get in touch for an itemised quote on the NINscope and our assembly and installation services, or buy the complete product in our online Store.
If you would like to purchase the items directly from multiple suppliers, please get in touch and we will send you the materials list.
Please remember that we are always happy to assist with assembly, testing and installation and we provide a warranty on our workmanship.
NeuroGig now offers the NINscope Kit to order, for self-assembly. The kit includes all the parts required to build a NINscope.
For design and assembly instructions please visit the GitHub repository at https://github.com/ninscope.
As part of our service, we offer assembly, testing and a workmanship warranty. So, if you have already purchased the materials or the NeuroGig NINscope Kit, but you struggle to find the time for the build or just don't have the patience...we are ready to help.
For a detailed summary of various miniscopes and integrated/miniaturised microscopes, please visit the publication by de Groot et al., 2019.
No, nothing unusual is needed for assembly, as long as you have the NeuroGig NINscope Kit or have sourced all the parts from the NINscope Bill of Materials.
NeuroGig has taken the time to put together a complete NINscope Bill of Materials, making it easier for you to source the parts.
It does, however, save you a lot of time and trouble when you only order from a single supplier and don't have to worry about minimum order quantity limitations. You can also rest assured that all parts in the NeuroGig NINscope Kit have been quality-checked.
This of course, depends entirely on personal preference, time, budget, technical skills and appetite for risk. Self-assembly has its advantages in gaining a better understanding of the technology and ensures simpler modifications in future. However, the cost in terms of technical learning and assembly time, as well as potential troubleshooting issues, may not make it worthwhile for you.
Possibly, yes. Depending on what it is you need. Please note that custom manufacturing may incur added cost and delivery may take longer. Please get in touch and tell us what your requirements are.